Ponte Biosciences, Inc. is a preclinical biotherapeutic company developing a cell-based bioartificial liver system, the Spheroid Reservoir Bioartificial Liver (SRBAL), to treat acute liver failure (ALF). The SRBAL was developed at the Mayo Clinic and utilizes metabolically active primary hepatocytes (liver cells) to replace or supplement liver function for Intensive Care Unit (ICU) patients. Ponte Biosciences, Inc. is based in Rochester, MN.